Everything about Dna Binding Protein totally explained
DNA-binding proteins are
proteins that comprise any of many
DNA-binding domains and thus have a specific or general affinity to
DNA.
DNA-binding
proteins include
transcription factors which
modulate the process of transcription,
nucleases which cleave DNA molecules, and
histones which are involved in DNA packaging in the
cell nucleus. DNA-binding proteins can incorporate such DNA-binding domains as the
zinc finger, the
helix-turn-helix, and the
leucine zipper (among many others).
Sequence-specific DNA-binding proteins generally interact with the
major groove of
B-DNA, because it exposes more
functional groups that identify a
base pair.
The specificity of DNA-binding proteins can be identified using the
DNase footprinting technique.
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